Dr O’Toole is currently Principal Investigator for a number of clinical trials in Head and Neck cancer treatment namely COMPARE, PATHOS, Best of and KeyNote 689 looking at improving outcomes for patients with the integration of immunotherapy into curative chemoradiotherapy and the best ways of treating patients postoperatively for oropharyngeal cancers. He is also Principal Investigator in the TRIGGER trial of advanced treatment of rectal cancer based on MRI response assessment post chemoradiotherapy. Also he has a keen interest in the development of the next generation of doctors and specifically oncologists. He actively participates in undergraduate teaching as an honorary senior lecturer and coordinates the training of clinical oncologists in his role as Royal College of Radiologist’s Tutor in Clinical Oncology.