Dr. Irmel A. Ayala
Pediatric Hematologist–Oncologist; Director, Hemophilia & Bleeding Disorders Treatment Center, Johns Hopkins All Children’s Hospital; Assistant Professor, Department of Pediatrics, University of South Florida.
United States
About the expert
Dr. Irmel Ayala is a pediatric hematologist–oncologist at Johns Hopkins All Children’s Hospital, where she has led the Hemophilia & Bleeding Disorders Treatment Center since 2003 and served in hematology leadership roles including division chief (2021–2024). Her clinical focus spans hemophilia and von Willebrand disease, thrombosis in children, and care for girls and young women with inherited bleeding disorders, coordinating a multidisciplinary clinic for menorrhagia. Her publications include work on pediatric VTE risk, immune cytopenias in primary immunodeficiency, and outcome measures in hemophilia. She also collaborates in an Immune Dysregulation Clinic for pediatric autoimmune cytopenias and contributes to multi-center studies in benign hematology.
Dr. Ayala earned her MD from the University of Puerto Rico School of Medicine (1986), completed pediatrics residency at San Juan City Hospital (1989), and a fellowship in pediatric hematology/oncology at Emory University (1993). She joined Johns Hopkins All Children’s Hospital in 2000 as a pediatric hematologist–oncologist.
Since 2003 she has directed the Hemophilia & Bleeding Disorders Treatment Center and established key clinical programs, including a Multidisciplinary Thrombosis Clinic (2007–2012) and the Young Women Bleeding Disorders/Menorrhagia Clinic (2015–present). She also helped co-found an Immune Dysregulation Clinic (2017–2022).
Her leadership has included Chief of Hematology/Oncology (2013–2017) and Chief of the Hematology Division (May 2021–Aug 2024). She is the medical director of the federally supported 340B Hemophilia program and has been site PI for CDC/ATHN public-health surveillance studies and national hemophilia cohorts.
Her scholarship spans pediatric VTE risk modeling and care pathways, immune cytopenias in primary immunodeficiency, heavy menstrual bleeding due to inherited bleeding disorders, and outcome metrics for modern hemophilia prophylaxis. She is active in the American Society of Pediatric Hematology/Oncology and the Hemophilia and Thrombosis Research Society.
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Chief
2022 - 2024Hematology Division, Cancer & Blood Disorders Institute, JH All Children’s.
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Founder & leader
2015 - TodayYoung Women Bleeding Disorders/Menorrhagia Clinic.
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Medical Director
2010 - Today340B Hemophilia Program.
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Chief
2013 - 2017Division of Hematology/Oncology
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Founder
2007 - 2012Multidisciplinary Thrombosis Clinic.
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Director
2003 - TodayHemophilia & Bleeding Disorders Treatment Center (federally funded comprehensive program).
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Board Certification, Pediatric Hematology/Oncology (ABP)
1998
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Board Certification, General Pediatrics (ABP): 1989
1989
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Fellowship, Pediatric Hematology/Oncology, Emory University, 1993.
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Residency, Pediatrics
San Juan City Hospital
1989
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MD
University of Puerto Rico School of Medicine
1986
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Children’s Oncology Group — Associate Member. (1996)
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American Society of Pediatric Hematology/Oncology. (2010)
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World Federation of Hemophilia. (2006)
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Hemophilia & Thrombosis Research Society. (2008)
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International Society on Thrombosis and Haemostasis. (2017)
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